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Dynamic metabolomic prediction from genetic variation
Nemčeková, Petra ; Weckwerth, Wolfram (referee) ; Schwarzerová, Jana (advisor)
Hordeum vulgare, tak ako mnoho ďalších plodín, trpí redukovaním genetickej rôznorodosti spôsobeným klimatickými zmenami. Preto je potrebné zlepšiť účinnosť jeho kríženia. Oblasť záujmu sa v poslednej dobe obracia na výskum nepriamych selekčných metód založených na výpočetných predikčných modeloch. Táto práca sa zaoberá dynamickou metabolomickou predikciou založenou na genomických dátach, ktoré pozostávajú z 33,005 jednonukleotidových polymorfizmov. Metabolomické dáta zahŕňajú 128 metabolitov 25 rodín Halle exotického jačmeňa. Hlavným cieľom tejto práce je vytvoriť metabolomické predikcie dynamických dát pomocou rôznych metód, ktoré boli vybrané na základe rôznych publikácií. Vytvorené modely napomôžu predikcii fenotypu alebo odhaleniu dôležitých vlastností rastliny Hordeum vulgare.
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Prediction of the Effect of Nucleotide Substitution Using Machine Learning
Šalanda, Ondřej ; Martínek, Tomáš (referee) ; Bendl, Jaroslav (advisor)
This thesis brings a new approach to the prediction of the effect of nucleotide polymorphism on human genome. The main goal is to create a new meta-classifier, which combines predictions of several already implemented software classifiers. The novelty of developed tool lies in using machine learning methods to find consensus over those tools, that would enhance accuracy and versatility of prediction. Final experiments show, that compared to the best integrated tool, the meta-classifier increases the area under ROC curve by 3,4 in average and normalized accuracy is improved by up to 7\,\%. The new classifying service is available at http://ll06.sci.muni.cz:6232/snpeffect/.
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Implementation of Sum Data Type in C++
Novák, Samuel Matyáš ; Roupec, Jan (referee) ; Matoušek, Radomil (advisor)
Práce se zaobírá problematikou implementace součtového datového typu v jazyce C++. Nejprve navrhuje vlastní abstrakce pro manipulaci s posloupnostmi hodnot a typů, které následně umožňují vyjadřovat komplexní operace deklarativně. V průběhu implementace jsou prezentovány návrhové vzory obvyklé pro oblast metaprogramování. Implementace přichází s rozhodnutími odlišnými od referenční implementace. Pro manipulaci se součtovým typem jsou představeny dvě šablony funkce, lišící se sémantikou. Užití součtového typu je ukázano na příkladu konečného stavového automatu.
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Design and Analysis of Reservation Teaching System
Jiříček, Milan ; Lukáš, Roman (referee) ; Fiala, Jiří (advisor)
In this bachelor's thesis there is a detailed description of an information systems analysis and design. An attention paid to implementation of such system is also specified in further details. Techniques of procedure designing of these systems using UML are described on a specific case of reservation teaching system. This information system works with specific events, either a regular class or a one-time event. Particular users of this system are able to carry out actions, which are linked with event management as well as with subjects or classrooms.
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Bioinformatic analysis of single nucleotide polymorphisms in the 1000 Genomes Project database
Parobková, Viktória ; Roy, Sudeep (referee) ; Provazník, Ivo (advisor)
Sekvenovanie celého ľudského genómu a nájdenie jeho variácii bolo výzvou počas mnohých rokov. Znalosť všetkých genetických variácií je pozoruhodne prospešná pri výskume chorôb. Táto práca je zameraná na genetické variácie človeka a ich dva hlavné výskumné projekty, The HapMap Project a The 1000 Genomes Project, ktoré pomohli v analýze chorôb. Prvá časť práce je venovaná teoretickému popisu projektov. V nasledujúcej časti práce sú popísané štruktúry databáz u oboch projektov a taktiež je predstavený online nástroj umožňujúci prehľadávanie a sťahovanie ich dát. Následne je prevedená štatistická, populačná a bioinformatická analýza štrukturálnych variácií produkovaných 3 fázou 1000 Genomes projektu.
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The study of polymorphism and optimization of active pharmaceutical ingredients crystallisation
Novák, David ; Ing.Ladislav Cvak, Ph.D. (referee) ; Ing.Roman Gabriel (advisor)
Active pharmaceutical ingredients (APIs) are frequently delivered to the patient in the solid-state as part of an approved dosage form (tablets, capsules, etc.). Understanding and controlling the solid-state chemistry of APIs is therefore an important aspect of the drug development process. APIs can exist in a variety of distinct solid forms, including polymorphs, solvates, hydrates, co-crystals and amorphous solids. Each form displays unique physicochemical properties that can profoundly influence the bioavailability, manufacturability, stability and other performance characteristics of the drug. Most APIs are purified and isolated by crystallisation from an appropriate solvent during the final step in synthetic process. The main objective of a crystallisation process is to produce crystals with desired properties such as particle size distribution (PSD), shape and purity. All pharmaceutical dosage forms must be produced in uniform units, and good content of uniformity is only possible when the size of the active component is carefully controlled. For on-line control of crystallisations of Quetiapine Fumarate to achieve desired PSD and no changed physicochemical purity was used the Lasentec Focus Beam Reflectance Measurement (FBRM) system.
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Polymorphism of dicalcium silicate
Matysík, Robert ; Fridrichová, Marcela (referee) ; Gazdič, Dominik (advisor)
The presented bachelor thesis is focused on the study of the mineral belite, polymorphism of belite, its conditions of origin and stability of polymorphs. The theoretical part is focused on the composition of cement, its minerals, modifications and properties. Furthermore, the possibilities of stabilization of polymorphs, synthesis and microstructure of dicalcium silicate are presented in the given section. The practical part is a summary of current research results at FAST BUT, THD. Based on previous work, a research was proposed in which a change in the properties of dicalcium silicate from a pre-fired mixture was observed.
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GUI for REPOMO
Šimek, Petr ; Růžička, Richard (referee) ; Sekanina, Lukáš (advisor)
Today, reconfigurable hardware is happend tendency when we can configure static circuit structure in the same way as software. REPOMO is a reconfigurable chip which contains 32 polymorphic gates. Polymorphism means that a gate can change its logic function as a response to the power supply voltage. The purpose of this thesis is to introduce the area of polymorphic circuits and construction and function of REPOMO chip. The main goal of the thesis is proposed and implemeted graphical user interface which make easy progress applications for chip REPOMO.
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